17-β-Estradiol: A Powerful Modulator of Blood–Brain Barrier BCRP Activity
نویسندگان
چکیده
منابع مشابه
17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity.
The ATP-driven efflux transporter, breast cancer resistance protein (BCRP), handles many therapeutic drugs, including chemotherapeutics, limiting their ability to cross the blood-brain barrier. This study provides new insight into rapid, nongenomic regulation of BCRP transport activity at the blood-brain barrier. Using isolated brain capillaries from rats and mice as an ex vivo blood-brain barr...
متن کاملA Review on 17-β estradiol a Potent Therapeutic Factor of Diabetic Cardiomyopathy
Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...
متن کاملEffects of 17-β estradiol on neurogenesis in the hippocampus of ovariectomized mice
Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...
متن کاملChronic estradiol - 17 β exposure increases superoxide production in the
1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5 hypertension. Therefore, we hypothesiz...
متن کاملPPAR- Contributes to the Anti-Inflammatory Activity of 17 -Estradiol
Because studies have shown that 17 -estradiol (E2) produces anti-inflammatory effects after various adverse circulatory conditions, we have recently demonstrated that E2 significantly reduced the acute lung injury. Moreover, previous results suggest that peroxisome proliferator-activated receptor(PPAR), an intracellular transcription factor activated by fatty acids, plays a role in the control ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2010
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2010.36